Cyclosporine A augments the regenerative response after partial hepatectomy in the rat.
نویسندگان
چکیده
منابع مشابه
Cyclosporine Augments Hepatic Regenerative Response in Rats
A number of mechanisms partlClpate in the hepatic injury that occurs during and following liver transplantation. A normal allograft regenerative response is probably essential for a successful transplant outcome. In this study. the effect of cyclosporine. a potent immunosuppressant used routinely after Ih'er transplantation. on the regeneratil'e response of the liver after partial hepatectomy w...
متن کاملEffect of in vivo administration of an antibody to epidermal growth factor on the rapid increase in DNA synthesis induced by partial hepatectomy in the rat.
Recent reports indicate that transforming growth factor alpha (TGF-alpha) is produced within the liver and acts as the natural ligand of the epidermal growth factor (EGF) receptor causing the EGF receptor down regulation and the hepatocyte proliferation observed after partial hepatectomy. The reported phenomenon that an antibody to EGF inhibits the regenerative response to partial hepatectomy w...
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Evidence could not be found of immune modulation of liver regeneration. The powerful immunosuppressive drug FK 506, which augments the response after partial hepatectomy in normal rats, had the same effect in T cell-deficient nude rats. The cytotoxicity of natural killer cells in treated nude rats was not significantly changed by FK 506 therapy. However, the serum of FK 506-treated nude rats in...
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The rapid regenerative response of the rat liver to partial hepatectomy is associated with a decline in liver epidermal growth factor receptor numbers which implies that ligand epidermal growth factor receptor interactions maybe important in initiating and/or modulating this process. The proliferative process in toxic hepatitis (where in contrast with partial hepatectomy the majority of hepatoc...
متن کاملEstradiol and testosterone levels in patients undergoing partial hepatectomy. A possible signal for hepatic regeneration?
In five adult male patients undergoing a 40-60% partial hepatectomy, serum sex hormone levels before and after hepatic resection were determined. Blood was drawn immediately prior to each surgical procedure and at specified time points postoperatively. Compared to hormone levels found prior to surgery, following major hepatic resection, estradiol levels increase at 24 and 48 hr, while testoster...
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ورودعنوان ژورنال:
- Transplantation proceedings
دوره 20 3 Suppl 3 شماره
صفحات -
تاریخ انتشار 1988